Heparan sulfate selectively inhibits the collagenase activity of cathepsin K
X. Zhang, Y. Luo, H. Hao, J. Krahn, G. Su, R. Dutcher, Y. Xu, J. Liu, L. Pedersen, D. Xu
This study shows heparan sulfate inhibits cathepsin K collagenase activity while preserving peptidase activity, revealing HS as a potential therapeutic target for bone resorption diseases.
Matrix Biology · May 1, 2024Peer-reviewedBiochemistry