Heparan sulfate promotes TRAIL-induced tumor cell apoptosis
Y. Luo, H. Hao, Z. Wang, C. Ong, R. Dutcher, Y. Xu, J. Liu, L. C. Pedersen, D. Xu
This study identifies heparan sulfate as a key regulator of TRAIL-induced apoptosis, showing that HS enhances TRAIL's apoptotic activity by promoting oligomerization and DR5 internalization.
bioRxiv · Jul 26, 2023Cell Biology