Author

L. Pedersen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Assay:flow cytometry· 1

Frequent Co-Authors

N. Halberg· 3 shared A. Molven· 2 shared C. E. Wogsland· 2 shared P. E. Lonning· 2 shared S. Knappskog· 2 shared S. M. Grondal· 2 shared A. Bergh· 1 shared A. Rulina· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCancer Biology

N. Halberg

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Author profile →

5 papers

Recent·Most cited

Heparan sulfate selectively inhibits the collagenase activity of cathepsin K

X. Zhang, Y. Luo, H. Hao, J. Krahn, G. Su, R. Dutcher, Y. Xu, J. Liu, L. Pedersen, D. Xu

This study shows heparan sulfate inhibits cathepsin K collagenase activity while preserving peptidase activity, revealing HS as a potential therapeutic target for bone resorption diseases.

Matrix Biology · May 1, 2024Peer-reviewedBiochemistry

Cytomegalovirus promotes proliferation and survival of prostate cancer cells and constitutes a therapeutic target

J. Classon, M. Stenudd, M. Zamboni, K. Alkass, C.-J. Eriksson, L. Pedersen, A. Schörling, A. Thoss, A. Bergh, P. Wikström, H.-O. Adami, H. T. Sorensen, H. Druid, J. Frisen

This study shows CMV infects prostate cancer cells, promotes their survival and proliferation, and can be targeted therapeutically with maribavir.

bioRxiv · Oct 1, 2023 · PreprintCancer Biology

High dimensional immunotyping of the obese tumor microenvironment reveals model specific adaptation

C. E. Wogsland, H. E. Lien, L. Pedersen, P. Hanjra, S. M. Grondal, R. Brekken, J. B. Lorens, N. Halberg

The paper uses high-dimensional mass cytometry to analyze immune responses in obese tumor models, revealing model-specific immune adaptations in pancreatic and breast cancer.

bioRxiv · Oct 14, 2020Cancer Biology

C/EBPB-dependent Adaptation to Palmitic Acid Promotes Stemness in Hormone Receptor Negative Breast Cancer

X. Liu, A. Rulina, M. H. Choi, L. Pedersen, J. Lepland, S. Takle, N. Madeleine, S. Peters, C. E. Wogsland, S. M. Grondal, J. Lorens, H. Goodarzi, A. Molven, P. E. Lonning, S. Knappskog, N. Halberg

The paper shows obesity-induced palmitic acid drives tumor initiation in hormone receptor negative breast cancer through C/EBPB-dependent transcriptional networks.

bioRxiv · Aug 11, 2020Cancer Biology

Golgi-localized PAQR4 mediates Anti-apoptotic Ceramidase Activity in Breast Cancer

L. Pedersen, P. Panahandeh, M. I. Siraji, S. Knappskog, P. E. Lonning, Q. Zhu, R. Gordillo, P. E. Scherer, A. Molven, K. Teigen, N. Halberg

This study identifies PAQR4 as a Golgi-localized ceramidase upregulated in breast cancer, whose depletion induces apoptosis by accumulating ceramides.

bioRxiv · Sep 18, 2019Cancer Biology