R. E. Diaz

This study characterizes the pH-specific enzymatic activity and ligand binding of mouse AMCase using structural and computational methods, revealing dual activity optima at pH 2 and 7.

This study shows that type 2 innate immunity, via ILC2s, regulates hair follicle homeostasis and maintains commensal Demodex mite colonization.

The paper identifies new chemical fragments binding to the SARS-CoV-2 Nsp3 macrodomain through crystallographic screening and computational docking, validating their binding with biophysical techniques.

This study identifies mutations that enhance chitinase activity on oligomeric substrates but not crystalline chitin, highlighting the importance of using physiologically relevant substrates in enzyme engineering.