Enhanced inflammatory response mediated by parenchymal cells associates with resistance towards mTOR inhibition
L. Jiao, R. Eickhoff, S. Jumpertz, J. Roth, M. Erdem, A. Kroh, H. Duimel, C. Lopez Iglesias, M. Schmeding, L. R. Heij, D. Meierhofer, U. P. Neumann, T. Cramer
This study shows that mTOR inhibition in liver epithelial cells enhances inflammation and accelerates liver metastases, suggesting non-malignant cells contribute to resistance against mTOR inhibitors.
bioRxiv · Aug 6, 2020 · PreprintCancer Biology