Author

M. Erdem

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

S. Jumpertz· 3 shared T. Cramer· 3 shared A. Fragoulis· 2 shared I. Rudolph· 2 shared A. A. Kuehl· 1 shared A. Egners· 1 shared A. Kroh· 1 shared C. E. Lewis· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCancer Biology

S. Jumpertz

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Author profile →

3 papers

Recent·Most cited

Enhanced inflammatory response mediated by parenchymal cells associates with resistance towards mTOR inhibition

L. Jiao, R. Eickhoff, S. Jumpertz, J. Roth, M. Erdem, A. Kroh, H. Duimel, C. Lopez Iglesias, M. Schmeding, L. R. Heij, D. Meierhofer, U. P. Neumann, T. Cramer

This study shows that mTOR inhibition in liver epithelial cells enhances inflammation and accelerates liver metastases, suggesting non-malignant cells contribute to resistance against mTOR inhibitors.

bioRxiv · Aug 6, 2020 · PreprintCancer Biology

Macrophages protect against loss of adipose tissue during cancer cachexia

M. Erdem, D. Moeckel, S. Jumpertz, C. John, A. Fragoulis, I. Rudolph, J. Wulfmeier, J. Springer, H. Horn, M. Koch, G. Lurje, T. Lammers, G. van der Kroft, F. Gremse, T. Cramer

This study shows that defective myeloid cell-mediated inflammation enhances cachexia in HCC mice, suggesting macrophages protect against fat loss in cancer cachexia.

bioRxiv · Sep 27, 2018Cancer Biology

Non-canonical HIF-1 stabilization is essential for intestinal tumorigenesis

N. Rohwer, S. Jumpertz, M. Erdem, A. Egners, K. T. Warzecha, A. Fragoulis, A. A. Kuehl, R. Kramann, S. Neuss, I. Rudolph, T. Endermann, C. Zasada, I. Apostolova, M. Gerling, S. Kempa, , T. Cramer

This study shows that non-canonical HIF-1 stabilization is crucial for intestinal tumorigenesis, independent of hypoxia, by affecting both epithelial and microenvironmental oncogenic processes.

bioRxiv · Feb 28, 2018Cancer Biology