Author

L. R. Heij

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

U. P. Neumann· 3 shared J. Bednarsch· 2 shared S. Sivakumar· 2 shared T. Luedde· 2 shared A. Easton· 1 shared A. Kroh· 1 shared A. Rendek· 1 shared C. Lopez Iglesias· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

U. P. Neumann

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cancer BiologybioRxivJun 30, 2023

Uncovering novel roles of miR-122 in the pathophysiology of the liver: Potential interaction with NRF1 and E2F4 signaling

M. Paluschinski, J. Schira-Heinen, R. Pellegrino…·M. Castoldi

This study identifies miR-122's role in liver disease by showing its antagonistic effects on NRF1 and E2F4 and its impact on proteins linked to malignancy.

DOI 10.3390/cancers15164129

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintAug 7, 2020

Nerve fibers in the Tumor Microenvironment are co-localized with Tertiary Lymphoid Structures

L. R. Heij, X. Tan, J. N. Kather…·U. P. Neumann

The paper analyzes nerve fiber density and tertiary lymphoid structures in pancreatic cancer, finding that high nerve fiber density and TLS count correlate with improved survival.

DOI 10.1101/2020.08.07.232322

humanimaging

𝕏 PostBluesky

Cancer BiologybioRxivPreprintAug 6, 2020

Enhanced inflammatory response mediated by parenchymal cells associates with resistance towards mTOR inhibition

L. Jiao, R. Eickhoff, S. Jumpertz…·T. Cramer

This study shows that mTOR inhibition in liver epithelial cells enhances inflammation and accelerates liver metastases, suggesting non-malignant cells contribute to resistance against mTOR inhibitors.

DOI 10.1101/2020.08.06.239426

mouseexperimental assay

𝕏 PostBluesky

ImmunologybioRxivPreprintJun 20, 2020

Immune responses in pancreatic cancer may be restricted byprevalence of activated regulatory T-cells, dysfunctionalCD8+ T-cells, and senescent T-cells

S. Sivakumar, E. Abu-Shah, D. Ahern…·M. Dustin

This study identifies immune cell states in pancreatic cancer, showing regulatory T-cells and dysfunctional CD8+ T-cells contribute to a suppressive microenvironment, suggesting new therapeutic targets.

DOI 10.1101/2020.06.20.163071

humanflow cytometry

𝕏 PostBluesky