T. Cramer

Broad diversity of human gut bacteria accessible via a traceable strain deposition system

The paper establishes a publicly available collection of 340 human gut bacterial strains, including 29 newly described species, and identifies plasmids and megaplasmids within these isolates.

The gut microbiome-linked long chain fatty acid stearate suppresses colorectal cancer

This study shows that the ketogenic diet reduces colorectal tumors in mice by altering the gut microbiome to increase stearic acid, which suppresses cancer cell growth and immune responses.

Conditional deletion of HIF-1α provides new insight regarding the murine response to gastrointestinal infection with Salmonella Typhimurium

This study investigates the role of HIF-1α in murine responses to Salmonella Typhimurium infection using conditional deletion, finding it dispensable or compensable in immune defense.

Enhanced inflammatory response mediated by parenchymal cells associates with resistance towards mTOR inhibition

This study shows that mTOR inhibition in liver epithelial cells enhances inflammation and accelerates liver metastases, suggesting non-malignant cells contribute to resistance against mTOR inhibitors.

Macrophages protect against loss of adipose tissue during cancer cachexia

This study shows that defective myeloid cell-mediated inflammation enhances cachexia in HCC mice, suggesting macrophages protect against fat loss in cancer cachexia.

Non-canonical HIF-1 stabilization is essential for intestinal tumorigenesis

This study shows that non-canonical HIF-1 stabilization is crucial for intestinal tumorigenesis, independent of hypoxia, by affecting both epithelial and microenvironmental oncogenic processes.

Rapid identification of optimal drug combinations for personalized cancer therapy using microfluidics

This paper presents a microfluidics-based method to rapidly screen drug combinations on patient cancer cells, identifying personalized treatment options validated in pancreatic cancer cell lines.