J. Roth

Molecular principles of redox-coupled sodium pumping of the ancient Rnf machinery

This study elucidates the molecular mechanism of redox-coupled sodium pumping in the Rnf complex using cryo-EM, biochemical assays, and simulations.

Primary Human Neutrophils and Monocytes/Macrophages Migrate along Endothelial Cell Boundaries to Optimize Search Efficiency

This study shows immune cells enhance search efficiency by migrating along endothelial cell boundaries, increasing sampled cells per distance and chemokine sensitivity.

Cytosolic S100A8/A9 promotes Ca2+ supply at LFA-1 adhesion clusters during neutrophil recruitment

The paper shows that cytosolic S100A8/A9 is essential for neutrophil adhesion under flow by regulating Ca2+ availability at LFA-1 adhesion clusters.

Increased plasma lipopolysaccharide-binding protein and altered inflammatory mediators in overweight women suggest a state of subclinical endotoxemia

This study finds higher plasma lipopolysaccharide-binding protein and pro-inflammatory mediators in overweight women, suggesting subclinical endotoxemia and inflammation linked to cardiovascular risk.

C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100A8 and S100A9

This study identifies C/EBPδ as a key regulator of S100A8 and S100A9 expression through epigenetic mechanisms in monocytes, with implications for inflammatory diseases.

PDXNet Portal: Patient-Derived Xenograft model, data, workflow, and tool discovery

The paper introduces the PDXNet Portal, a centralized resource for PDX models and data, offering analysis workflows and facilitating cancer research collaboration.

2.5D Tractions in monocytes reveal mesoscale mechanics of podosomes during substrate indenting cell protrusion

This study examines mesoscale mechanical forces in podosome clusters of monocytes, revealing that collective behavior arises from network contraction and buckling, not just individual podosome mechanics.

Enhanced inflammatory response mediated by parenchymal cells associates with resistance towards mTOR inhibition

This study shows that mTOR inhibition in liver epithelial cells enhances inflammation and accelerates liver metastases, suggesting non-malignant cells contribute to resistance against mTOR inhibitors.

Extratubular polymerized uromodulin induces leukocyte recruitment and inflammation in vivo

This study shows extratubular polymerized uromodulin induces inflammation by recruiting leukocytes and affecting vascular permeability in vivo.

Endothelial basement membrane laminins as an environmental cue in monocyte differentiation to macrophages.

This study shows that endothelial basement membrane laminins 411 and 511 influence monocyte differentiation to macrophages by modulating migration and integrin profiles.

Calprotectin modulates inflammatory collateral tissue damage during intraperitoneal origin systemic candidiasis

This study shows that S100A8/A9 modulates inflammatory collateral tissue damage and fungal clearance during systemic candidiasis, with paquinimod reducing ICTD.

Systematic Establishment of Robustness and Standards in Patient-Derived Xenograft Experiments and Analysis

The paper tests the reproducibility of PDX drug responses and sequence results across different labs using standardized protocols and workflows.