A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation
M. C. Kiritsy, L. M. Ankley, J. D. Trombley, G. P. Huizinga, A. E. Lord, P. Orning, R. Elling, K. A. Fitzgerald, A. Olive
This study identifies new regulators of IFNγ-induced MHCII in macrophages using CRISPR screens, revealing pathways involving GSK3β and MED16 that are critical for CD4+ T cell activation.
bioRxiv · Aug 12, 2020Immunology