Author

P. Orning

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. E. Lord· 1 shared A. Olive· 1 shared C. Wu· 1 shared D. Weng· 1 shared E. Lien· 1 shared G. P. Huizinga· 1 shared H. Zhang· 1 shared J. D. Trombley· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

A. E. Lord

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2 papers

Recent·Most cited

A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation

M. C. Kiritsy, L. M. Ankley, J. D. Trombley, G. P. Huizinga, A. E. Lord, P. Orning, R. Elling, K. A. Fitzgerald, A. Olive

This study identifies new regulators of IFNγ-induced MHCII in macrophages using CRISPR screens, revealing pathways involving GSK3β and MED16 that are critical for CD4+ T cell activation.

bioRxiv · Aug 12, 2020Immunology

RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages

L. Tao, Y. Yi, Y. Chen, H. Zhang, J. Jie, W. Zhang, Q. Xu, Y. Li, P. Orning, E. Lien, M. Zhao, P. Gao, L. Ling, Z. Ding, C. Wu, , D. Weng

This study shows that RIP1 kinase activity in macrophages drives steatohepatitis by promoting cell death and inflammation, and its inhibition reduces liver injury in NASH models.

bioRxiv · Jan 7, 2020Immunology