Cyclin F-Chk1 synthetic lethality mediated by E2F1 degradation
V. D'Angiolella, H. Yang, R. Faedda, S. Hume, D. Ebner, S. B. Hatch, B. Kessler, K. Burdova, I. Vendrell, D. H. Drewry, C. I. Wells
The paper identifies synthetic lethality between Chk1 inhibition and cyclin F loss, revealing Cyclin F's role in preventing DNA replication stress via E2F1 degradation.
bioRxiv · Jan 2, 2019 · PreprintCancer Biology