Author

B. Kessler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Microbiology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

I. Vendrell· 3 shared E. Kemter· 2 shared E. Wolf· 2 shared M. Kurome· 2 shared N. Klymiuk· 2 shared R. Fischer· 2 shared V. Zakhartchenko· 2 shared A. A. Ahmed· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCancer Biology

I. Vendrell

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

LARP1 regulates metabolism and mTORC1 activity in cancer

J. Chettle, Z. Dedeic, R. Fischer, I. Vendrell, L. Campo, A. Easton, M. Browne, J. Morris, H. Schwenzer, P. Lascaux, R. Gijsbers, E. Pires, D. J. Royston, D. J. P. Ferguson, A. Coosemans, , S. P. Blagden

This study identifies LARP1 as a key regulator of metabolism and mTORC1 activity in cancer, showing its role in sustaining cellular metabolism and driving cancer progression.

bioRxiv · Sep 4, 2022 · PreprintCancer Biology

Deep proteomics network and machine learning analysis of human cerebrospinal fluid in Japanese encephalitis virus infection

T. Bharucha, B. Gangadharan, A. Kumar, A. C. Myall, N. Ayhan, B. Pastorino, A. Chanthongthip, M. Vongsouvath, M. Mayxay, O. Sengvilaipaseuth, S. Rattanavong, D. P. O'Brien, I. Vendrell, R. Fischer, B. Kessler, , SEAe collaborators

This study identifies a ten-protein diagnostic signature for Japanese encephalitis virus infection in cerebrospinal fluid with >99% accuracy using proteomics and machine learning.

bioRxiv · Jun 19, 2022Microbiology

A scalable, clinically severe pig model for Duchenne muscular dystrophy

M. Stirm, L. M. Fonteyne, B. Shashikadze, M. Lindner, M. Chirivi, A. Lange, C. Kaufhold, C. Mayer, I. Medugorac, B. Kessler, M. Kurome, V. Zakhartchenko, A. Hinrichs, E. Kemter, S. Krause, , E. Wolf

This paper develops a scalable pig model for Duchenne muscular dystrophy by breeding DMD carriers, enabling large cohorts for disease mechanism studies and therapeutic testing.

Disease Models & Mechanisms · Dec 1, 2021Peer-reviewedPathology

Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs

E. Kemter, A. Müller, M. Neukam, A. Ivanova, N. Klymiuk, S. Renner, K. Yang, J. Broichhagen, M. Kurome, V. Zakhartchenko, B. Kessler, K.-P. Knoch, M. Bickle, B. Ludwig, K. Johnsson, , M. Solimena

This study develops a transgenic pig model with SNAP-tagged insulin to investigate in vivo insulin secretory granule dynamics and turnover.

bioRxiv · Apr 23, 2021Cell Biology

Reduced PABPN1 levels causes cytoskeleton disorganization and aberrant differentiation

V. Raz, E. van der Wal, C. Domagoj, C. S. Olie, L. Maton, J. C. de Greef, I.-H. Lin, Y.-F. Chen, E. Kareem, J. M. Penninger, B. Kessler

This study shows that reduced PABPN1 levels disrupt cytoskeletal organization and impair muscle differentiation, with actin overexpression improving these defects.

bioRxiv · Jan 15, 2020 · PreprintCell Biology

Lipocalin-2 is a Sensitive and Specific Marker of Bacterial Infection in Children

J. Herberg, H. Huang, M. L. Thezenas, V. Janes, M. Carter, S. Gormley, M. S. Hamilton, B. Kessler, M. Levin, C. Casals-Pascual

This study evaluates LCN2 and MMP-8 as biomarkers for predicting serious bacterial infection in children, finding LCN2 to be sensitive and specific with superior performance when combined with CRP.

bioRxiv · Apr 30, 2019 · PreprintMicrobiology

Cyclin F-Chk1 synthetic lethality mediated by E2F1 degradation

V. D'Angiolella, H. Yang, R. Faedda, S. Hume, D. Ebner, S. B. Hatch, B. Kessler, K. Burdova, I. Vendrell, D. H. Drewry, C. I. Wells

The paper identifies synthetic lethality between Chk1 inhibition and cyclin F loss, revealing Cyclin F's role in preventing DNA replication stress via E2F1 degradation.

bioRxiv · Jan 2, 2019 · PreprintCancer Biology