MicrobiologybioRxiv
Emergence of compensatory mutations reveal the importance of electrostatic interactions between HIV-1 integrase and genomic RNA
C. Shema Mugisha, T. Dinh, A. Kumar…·S. Kutluay
This study identifies compensatory mutations that restore HIV-1 integrase-gRNA binding and infectivity, revealing the role of electrostatic interactions in this process and their impact on allosteric inhibitor sensitivity.
DOI 10.1128/mbio.00431-22