Cell BiologybioRxiv
Human pseudoislet system enables detection of differences in G-protein-coupled-receptor signaling pathways between α and β cells
J. T. Walker, R. Haliyur, H. A. Nelson…·M. Brissova
The paper develops a pseudoislet system to study GPCR signaling differences between human α and β cells, showing distinct effects of Gi and Gq pathway activations on hormone secretion.
DOI 10.1172/jci.insight.137017