Enhancing mitochondrial pyruvate metabolism ameliorates myocardial ischemic reperfusion injury.
J. R. Visker, A. A. Cluntun, J. N. Velasco-Silva, D. R. Eberhardt, T. S. Shankar, R. Hamouche, J. Ling, H. Kwak, Y. Hillas, I. Aist, E. Tseliou, S. Navankasattusas, D. Chaudhuri, G. S. Ducker, S. G. Drakos, J. Rutter
This study shows that inhibiting MCT4 to redirect pyruvate metabolism reduces myocardial ischemia-reperfusion injury by improving mitochondrial function and reducing oxidative stress.
bioRxiv · Feb 1, 2024 · PreprintPhysiology