J. Rutter

SLC7A5 is required for citrulline-dependent growth in arginine limited conditions

This study identifies SLC7A5 as essential for citrulline-dependent growth in arginine-limited conditions and shows its role in citrulline uptake and tumor growth.

Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis

The paper shows that inhibiting lactate transporters MCT1 and MCT4 reduces myofibroblast differentiation and pulmonary fibrosis in vitro and in vivo.

Enhancing mitochondrial pyruvate metabolism ameliorates myocardial ischemic reperfusion injury.

This study shows that inhibiting MCT4 to redirect pyruvate metabolism reduces myocardial ischemia-reperfusion injury by improving mitochondrial function and reducing oxidative stress.

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity

FALCON systematically analyzes 61 free fatty acids to identify lipotoxic effects and a novel mediator of lipotoxicity, CMIP, in human pancreatic beta cells.

Phosphatidylethanolamine facilitates mitochondrial pyruvate entry to regulate metabolic flexibility

This study identifies phosphatidylethanolamine's role in regulating mitochondrial pyruvate entry, linking it to metabolic flexibility in skeletal muscle.

Phosphate Starvation Signaling Increases Mitochondrial Membrane Potential through Respiration-independent Mechanisms

The paper shows phosphate starvation increases mitochondrial membrane potential through respiration-independent mechanisms in yeast and mammalian cells.

Mitochondrial Phosphatidylethanolamine Directly Regulates UCP1 to Promote Brown Adipose Thermogenesis

This study shows mitochondrial phosphatidylethanolamine directly regulates UCP1 to control thermogenesis in brown adipose tissue.

Protein-Metabolite Interactomics Reveals Novel Regulation of Carbohydrate Metabolism

The paper develops the MIDAS platform to identify protein-metabolite interactions, revealing novel regulatory mechanisms in carbohydrate metabolism.

Mitochondrial pyruvate supports lymphoma proliferation by fueling a non-canonical glutamine metabolism pathway

This study identifies a non-canonical glutamine metabolism pathway in DLBCLs where mitochondrial pyruvate supports glutaminolysis and proliferation, particularly in solid extracellular matrix environments.

Laterally transferred macrophage mitochondria acts as a signaling source promoting cancer cell proliferation

The paper shows that dysfunctional macrophage mitochondria transferred to cancer cells promote proliferation via ROS-induced ERK signaling.

Co-deletion of ATAD1 with PTEN primes cells for BIM-mediated apoptosis

The paper shows that co-deletion of ATAD1 with PTEN makes cancer cells more susceptible to apoptosis via BIM activation, correlating with better patient survival.

Protective mitochondrial fission induced by stress responsive protein GJA1-20k

This study identifies GJA1-20k as a stress-responsive protein that induces non-canonical mitochondrial fission to protect against ischemia-reperfusion injury.

Serine Palmitoyltransferase Controls Stemness of Intestinal Progenitors

The paper shows that serine palmitoyltransferase (SPT) modulates intestinal stem cell homeostasis by promoting stemness through sphingolipid production and PPAR-alpha activation, linking diet to cancer risk.

Msp1/ATAD1 restores mitochondrial function in Zellweger Spectrum Disease

The paper investigates peroxisomal dysfunction in Zellweger Spectrum Disease and shows that overexpressing ATAD1 restores mitochondrial function in patient-derived fibroblasts.

Network-aware reaction pattern recognition reveals regulatory signatures of mitochondrial dysfunction

The paper introduces Metaboverse, a tool for network-aware reaction pattern recognition in metabolic data, identifying regulatory signatures of mitochondrial dysfunction in lung adenocarcinoma and respiratory deficiency models.

Mitochondrial fatty acid synthesis coordinates mitochondrial oxidative metabolism

This study shows that mitochondrial fatty acid synthesis (mtFAS) regulates electron transport chain (ETC) complexes and skeletal myoblast differentiation, linking fatty acid synthesis to oxidative metabolism.

Crystal structure and interaction studies of human DHTKD1 provide insight into a mitochondrial megacomplex in lysine catabolism

This study presents the crystal structure of human DHTKD1 and a 3D reconstruction of the DLST inner core, revealing structural insights into lysine catabolism and potential drug targets.

Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis

This study shows that mitochondrial pyruvate carrier is essential for optimal brown fat thermogenesis, as its deletion impairs cold adaptation and alters metabolic pathways.

Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity

The paper shows that mitochondrial phospholipids, specifically phosphatidylethanolamine (PE), regulate respiratory capacity in skeletal muscle, with PE deficiency causing respiratory failure and oxidative stress.

Antibiotic collateral sensitivity is contingent on the repeatability of evolution

This study shows that sequential antibiotic treatments may overestimate therapeutic benefits due to stochastic resistance or susceptibility outcomes in E. coli.

Oct1/Pou2f1 is selectively required for gut regeneration and regulates gut malignancy

This study shows Oct1/Pou2f1 is essential for gut regeneration but has opposing roles in colon cancer depending on the tumor model.

Vms1p is a release factor for the Ribosome-associated Quality control Complex

This study identifies Vms1p as the tRNA hydrolase that releases nascent polypeptides in the RQC pathway for degradation.

Global analysis of plasma lipids identifies liver-derived acyl-carnitines as a fuel source for brown fat thermogenesis

This study identifies liver-derived acyl-carnitines as a fuel source for brown fat thermogenesis, showing that cold exposure increases plasma acylcarnitine levels through hepatic HNF4 activation and that carnitine supplementation improves thermogenic response in aged mice.