D. Chaudhuri

Enhancing mitochondrial pyruvate metabolism ameliorates myocardial ischemic reperfusion injury.

This study shows that inhibiting MCT4 to redirect pyruvate metabolism reduces myocardial ischemia-reperfusion injury by improving mitochondrial function and reducing oxidative stress.

Mitochondria possess a large, non-selective ionic current that is enhanced during cardiac injury.

The paper identifies a large, non-selective ionic current in mitochondria, called LUNA, which increases during cardiac injury and is inhibited by amiloride.

F-box protein FBXB-65 regulates anterograde transport of UNC-104 through modification near the PH domain

This study shows FBXB-65 regulates UNC-104 anterograde transport by modifying it near the PH domain, affecting cargo transport efficiency and motor dynamics.

Mitochondrial Phosphatidylethanolamine Directly Regulates UCP1 to Promote Brown Adipose Thermogenesis

This study shows mitochondrial phosphatidylethanolamine directly regulates UCP1 to control thermogenesis in brown adipose tissue.

Trimethylamine N-oxide (TMAO) enhances substrate mechanical stability probed by single molecule magnetic tweezers

This study investigates how TMAO affects the mechanical stability of proteins using single-molecule magnetic tweezers, finding it increases unfolding force and alters folding kinetics.

Talin-drug interaction reveals a key molecular determinant for biphasic mechanical effect: studied under single-molecule resolution

This study investigates talin-drug interactions using single-molecule techniques, revealing biphasic mechanical effects and mechanistic insights into drug-induced stability changes.

Deceiving The Big Eaters: Salmonella Typhimurium SopB subverts host cell Xenophagy through the Akt-TFEB axis in macrophages

This study shows Salmonella Typhimurium uses SopB to inhibit host autophagy by disrupting phosphoinositide dynamics and the Akt-TFEB axis, aiding bacterial survival and dissemination.

EFHD1 ablation reduces cardiac mitoflash activation and protects cardiomyocytes from ischemia.

This study shows that EFHD1 deletion reduces mitochondrial Ca2+ overload and ROS production, protecting cardiomyocytes from ischemia-induced injury.

DsbA is a redox-switchable mechanical chaperone

This study shows DsbA acts as a redox-switchable mechanical chaperone, reducing ATP consumption for periplasmic translocation by up to 33%.

Real time observation of chaperone-modulated talin mechanics under single molecule resolution

This study investigates how chaperones modulate talin mechanics under single-molecule resolution, showing they alter unfolding forces and energy landscapes.

Direct observation of the mechanical role of bacterial chaperones in protein folding

The paper uses magnetic-tweezers to study how chaperones respond to mechanical force, revealing their roles in generating or consuming energy during protein folding.

Connecting conformational stiffness of the protein with energy landscape by a single experiment

This paper introduces a method to simultaneously measure multiple physical properties of a single protein molecule in real-time, revealing how salt concentration affects its conformational flexibility and energy landscape.

Cell boundary confinement sets the size and position of the E. coli chromosome

This study shows that spatial confinement in E. coli determines chromosome size and position, with simulations supporting depletion effects from cytosolic crowders.