R. Hershberg

This study examines genetic adaptation in Pseudomonas putida during prolonged resource exhaustion, showing convergent mutation patterns and mutator emergence, with some similarities to Escherichia coli.

This study shows compensatory mutations do not fully offset rifampicin resistance costs and mostly occur outside the drug target, with convergent pathways across populations.

This study shows E. coli maintains genetic memory of prior metabolic adaptations, enabling rapid re-adaptation to consume butyrate after resource exhaustion.

The paper shows that mutations in highly conserved RNA polymerase core enzyme positions drive rapid adaptation in bacteria, but these same positions are also more conserved in nature, suggesting potential antagonistic pleiotropy.

The paper models growth and death dynamics of E. coli strains, showing that density-dependent inhibition and resource efficiency, not growth/death rates, explain strain variability.

This study shows that high mutation rates increase reversion to wild type when compensation is partial, but fully compensatory mutations reduce reversion probability.

This study shows that culture volume affects genetic adaptation dynamics in E. coli during long-term stationary phase, with higher volumes leading to stronger positive selection on mutations.

This study tracks genetic adaptation and mutation dynamics in E. coli over three years in long-term stationary phase, showing convergent mutation accumulation and varying mutation rates among clones.

This study shows that genetic adaptations in E. coli under prolonged resource exhaustion are rapidly purged when resources are restored, and recovery depends on mutator status.