Author

R. Huhtaniemi

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Biology Disciplines

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Cancer Biology· 1

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Kaur· 1 shared C. von Schantz-Fant· 1 shared J. Merisaari· 1 shared J. Westermarck· 1 shared K. Wennerberg· 1 shared L. Yetukuri· 1 shared M. Jumppanen· 1 shared M. Ohlmeyer· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. Kaur

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintMay 31, 2022

Pharmacological PP2A reactivation overcomes multikinase inhibitor tolerance across brain tumor cell models

O. Denisova, J. Merisaari, R. Huhtaniemi…·J. Westermarck

This study identifies a triplet therapy combining AKT, PDK1-4 inhibition, and PP2A reactivation that effectively eradicates brain tumor models by overcoming kinase inhibitor tolerance through combinatorial effects on signaling rewiring, OXPHOS, and apoptosis.

DOI 10.1101/2022.05.31.494146

humanproteomics

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