Cancer BiologybioRxivPreprint
Developing Small Molecules that Inhibit K-Ras/GTP Binding Based on New Affinity Measurements
L. Carta, R. Hutcheson, S. A. Davis…·Y. R. Hadari
The paper reports new affinity measurements of K-Ras and its mutants for GTP, showing a 10,000-fold lower affinity than previously thought, and identifies over 400 small molecules that inhibit GTP binding to K-Ras.
DOI 10.1101/2020.07.27.218248