Author

M. Quick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:structural biology· 6 Organism:bacteria (other)· 4 Research Focus:protein folding & dynamics· 4 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

B. Kloss· 2 shared F. Mancia· 2 shared J. A. Javitch· 2 shared O. B. Clarke· 2 shared A. C. Schwartz· 1 shared A. Eguskiza· 1 shared A. K. Kossiakoff· 1 shared A. R. Reckers· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

B. Kloss

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Alternating Access of a Neurotransmitter:Sodium Symporter Bacterial Homolog Determined from AlphaFold2 Ensembles and DEER Spectroscopy

A. C. Schwartz, R. A. Stein, E. Gil-Itrube, M. Quick, H. S. Mchaourab

This paper uses AlphaFold2 and DEER spectroscopy to study the conformational dynamics of MhsT, revealing energy landscapes and environmental effects on transporter function.

bioRxiv · Apr 8, 2024 · PreprintBiophysics

Structural and molecular basis of choline uptake into the brain by FLVCR2

R. J. Cater, D. Mukherjee, E. Gil Iturbe, S. K. Erramilli, T. Chen, K. Koo, N. G. Santander, A. R. Reckers, B. Kloss, T. Gawda, B. C. Choy, Z. Zhang, O. B. Clarke, S. W. Yee, A. K. Kossiakoff, , F. Mancia

This study identifies FLVCR2 as the primary choline transporter at the blood-brain barrier, determines its structures, and elucidates its mechanism of choline uptake.

bioRxiv · Oct 5, 2023Biochemistry

Insight into the mechanism of H+-coupled nucleobase transport

J. Weng, X. Zhou, P. Wiriyasermkul, Z. Ren, X. Yan, K. Chen, E. G. Iturbe, M. Zhou, M. Quick

The paper reports the structure and function of PurTCp, a NAT family transporter from Colwellia psychrerythraea, showing it transports purines via H+-dependent mechanism and identifies a critical aspartate residue.

bioRxiv · Dec 20, 2021 · PreprintBiochemistry

Developing Small Molecules that Inhibit K-Ras/GTP Binding Based on New Affinity Measurements

L. Carta, R. Hutcheson, S. A. Davis, M. J. Rudolph, C. H. Reynolds, M. Quick, T. M. Williams, M. Schmertzler, Y. R. Hadari

The paper reports new affinity measurements of K-Ras and its mutants for GTP, showing a 10,000-fold lower affinity than previously thought, and identifies over 400 small molecules that inhibit GTP binding to K-Ras.

bioRxiv · Jul 27, 2020 · PreprintCancer Biology

Role of transmembrane helix 6 in substrate recognition of the amino acid transporter MhsT

P. Nissen, M. Quick, R. Blunck, J. Lyons, C. M. T. Neumann, D. Focht, J. A. Javitch, A. Eguskiza, L. Malinauskaite, I. O. Schwarz

The paper investigates how the flexibility of a GMG motif in TM6 of MhsT enables substrate recognition of different amino acid sizes by shaping the binding site.

bioRxiv · Apr 3, 2020 · PreprintBiochemistry

The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor

M. V. LeVine, D. S. Terry, G. Khelashvili, Z. S. Siegel, M. Quick, J. A. Javitch, S. C. Blanchard, H. Weinstein

The paper identifies an allosteric mechanism involving residues F259 and I359 that modulates Na+ release and substrate transport in SLC6 family proteins.

bioRxiv · Feb 20, 2019Biophysics

Structure-based analysis of CysZ-mediated cellular uptake of sulfate

Z. Assur Sanghai, Q. Liu, O. B. Clarke, E. Leal Pinto, B. Kloss, S. Tabuso, J. Love, M. Punta, S. Banerjee, K. R. Rajashankar, B. Rost, D. Logothetis, M. Quick, W. A. Hendrickson, F. Mancia

The paper investigates the molecular mechanism of CysZ-mediated sulfate uptake using structural and functional analyses.

bioRxiv · Apr 27, 2017Biophysics