Disruption of the PGE2 synthesis / response pathway restrains atherogenesis in programmed cell death-1 (Pd-1) deficient hyperlipidemic mice
E. Ricciotti, S. Y. Tang, A. Mrcela, U. Das, R. Lordan, R. Joshi, S. Ghosh, J. Aoyama, R. McConnell, J. Yang, G. R. Grant, G. A. FitzGerald
This study shows that disrupting the PGE2 synthesis or response pathway reduces atherogenesis in PD-1 deficient hyperlipidemic mice through different immune mechanisms.
bioRxiv · Jul 2, 2024 · PreprintPharmacology & Toxicology