R. Joshi

Joint tracking of active and passive motion in the mouse visual thalamus during natural behaviour

The paper investigates how neurons in the mouse visual thalamus represent active and passive motion during natural behavior and finds that they can track both types of motion and partially separate them.

Disruption of the PGE2 synthesis / response pathway restrains atherogenesis in programmed cell death-1 (Pd-1) deficient hyperlipidemic mice

This study shows that disrupting the PGE2 synthesis or response pathway reduces atherogenesis in PD-1 deficient hyperlipidemic mice through different immune mechanisms.

Revealing the Biophysics of Lamina-Associated Domain Formation by Integrating Theoretical Modeling and High-Resolution Imaging

This study combines theoretical modeling and high-resolution imaging to reveal how chromatin-lamina interactions and environmental cues influence LAD formation and thickness in hMSCs.

KF4 anti-CELA1 Antibody and Purified α1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine α1-Antitrypsin Deficiency

This study evaluates KF4 anti-CELA1 antibody and purified α1-antitrypsin in preventing emphysema in AAT-deficient mice, finding similar efficacy with no additive benefit when combined.

Curcumin Inhibits Zika Virus NS3 Helicase Activity

This study investigates curcumin's inhibitory effect on ZIKV NS3 helicase activity, finding it interacts with the enzyme and inhibits NTPase activity with an IC50 of 64.42 μM.

Horizontally transferred cell-free chromatin particles function as autonomous satellite genomes and vehicles for transposable elements within host cells

Chromatin condensation delays human mesenchymal stem cells senescence by safeguarding nuclear damages during long-term in vitro expansion

Therapeutic interventions on human xenografts promote systemic dissemination of oncogenes

The paper shows that therapeutic interventions in human xenografts increase oncogene dissemination, which can be reduced by chromatin deactivating agents.

Formulation development and comparability studies with an aluminum-salt adjuvanted SARS-CoV-2 Spike ferritin nanoparticle vaccine antigen produced from two different cell lines

This study develops and compares an aluminum-salt adjuvanted SARS-CoV-2 Spike ferritin nanoparticle vaccine antigen produced in two cell lines, showing similar immunogenicity despite differences in glycoforms.

Chromatin Acetylation Overrides Substrate Stiffness-Dependent Mechanoresponse and Lineage Specification in Human Mesenchymal Stem Cells

This study shows that chromatin acetylation overrides substrate stiffness effects on hMSCs phenotype and lineage specification by reprogramming mechanoresponse and fate decisions.

Identification of Cancer-Associated Fibroblasts in Glioblastoma and Defining Their Pro-tumoral Effects

The paper identifies cancer-associated fibroblasts in glioblastoma and shows their pro-tumoral effects through interactions with glioblastoma stem cells.

Comparative MD simulations and advanced analytics based studies on wild-type and hot-spot mutant A59G HRas

This study uses MD simulations and advanced analytics to compare wild-type and A59G mutant HRas, finding that the mutant lacks a pre-hydrolysis network, leading to a permanently active oncogenic state.

GSMN-ML- a genome scale metabolic network reconstruction of the obligate human pathogen Mycobacterium leprae

This paper reconstructs a genome-scale metabolic network for Mycobacterium leprae to study its metabolism and identify potential drug targets.

Soft Substrate Maintains Proliferative and Multi-lineage Potential of Human Mesenchymal Stem Cells on Long Term Expansion

This paper shows that culturing human mesenchymal stem cells on soft polyacrylamide gel maintains their stemness by delaying senescence compared to traditional tissue culture plates.