Cancer BiologybioRxivPreprint
The linkage of methionine addiction, overmethylation of histone H3 lysines and malignancy demonstrated when cancer cells revert to methionine-independence
J. Yamamoto, S. Inubushi, Q. Han…·R. M. Hoffman
The paper shows that methionine-independent cancer cell revertants have reduced histone H3 lysine trimethylation and lower tumorigenicity and metastatic potential compared to methionine-addicted parental cells.