Author

K. Miyake

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Assay:proteomics· 2

Frequent Co-Authors

M. Taoka· 3 shared R. Fukui· 3 shared R. Sato· 3 shared T. Isobe· 3 shared T. Shibata· 3 shared Y. Motoi· 3 shared Y. Yamauchi· 3 shared E. Fujita· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersImmunology

M. Taoka

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Basophils drive the resolution and promote wound healing in adult and aged mice

J. Bex, V. Peter, C. Saji, L. Chapart, S. Jin, G. Gauthier, O. Thibaudeau, M. K. Thaminy, J. Tchen, Q. Simon, X. Dai, K. Miyake, H. Karasuyama, J. X. Jiang, K. Naidoo, , C. Pellefigues

This study shows basophils promote inflammation resolution and wound healing in both adult and aged mice by driving tissue remodeling and immunoregulatory functions.

bioRxiv · Jul 2, 2024Immunology

A stress sensor IRE1α is required for bacterial exotoxin-induced inflammasome activation in tissue-resident macrophages

I. Sasaki, Y. Fukuda-Ohta, C. Nakai, N. Wakaki-Nishiyama, C. Okamoto, T. Orimo, D. Okuzaki, S. Morita, S. Kaji, Y. Furuta, H. Hemmi, T. Kato, A. Yamamoto, T. Tanaka, K. Hoshino, , T. Kaisho

The paper shows that IRE1α is essential for CTB and CT-induced IL-1β production in tissue-resident macrophages via NLRP3 and pyrin inflammasomes.

bioRxiv · Jul 6, 2023 · PreprintImmunology

Microbiome ssRNA as an environmental cue to activate TLR13-dependent tissue-protective programs in CD5Lhi hepatic macrophages

R. Sato, K. Liu, T. Shibata, K. Hoshino, K. Yamaguchi, T. Miyazaki, R. Hiranuma, R. Fukui, Y. Motoi, Y. Fukuda-Ohta, Y. Zhang, T. Reuter, Y. Ishida, T. Kondo, T. Chiba, , K. MIYAKE

The paper shows that microbiome ssRNA activates TLR13 in hepatic macrophages to drive tissue-protective responses, leading to resistance against acute liver injury in Rnaset2-/- mice.

bioRxiv · May 11, 2023 · PreprintImmunology

TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

K. Miyake, T. Shibata, R. Sato, M. Taoka, S.-I. Saitoh, M. Komine, K. Yamaguchi, S. Goyama, Y. Motoi, J. Kitaura, K. Izawa, Y. Yamauchi, Y. Tsukamoto, T. Ichinohe, E. Fujita, , T. Taguchi

This study identifies TLR7/8 as drivers of histiocytosis in SLC29A3 disorders by responding to lysosomal nucleoside stress and enhancing monocyte proliferation and phagocyte maturation.

bioRxiv · Oct 27, 2022Immunology

The linkage of methionine addiction, overmethylation of histone H3 lysines and malignancy demonstrated when cancer cells revert to methionine-independence

J. Yamamoto, S. Inubushi, Q. Han, Y. Tashiro, N. Sugisawa, K. Hamada, Y. Aoki, K. Miyake, R. Matsuyama, M. Bouvet, S. G. Clarke, I. Endo, R. M. Hoffman

The paper shows that methionine-independent cancer cell revertants have reduced histone H3 lysine trimethylation and lower tumorigenicity and metastatic potential compared to methionine-addicted parental cells.

bioRxiv · Dec 4, 2020 · PreprintCancer Biology

Nucleosides drive histiocytosis in SLC29A3 disorders by activating TLR7

T. Shibata, M. Taoka, S.-I. Saitoh, Y. Yamauchi, Y. Motoi, M. Komine, E. Fujita, R. Sato, H. Sagara, T. Ichinohe, M. Kawazoe, C. Kato, K. Furusho, Y. Murakami, R. Fukui, , K. MIYAKE

This study shows that TLR7 activation by accumulated nucleosides in lysosomes drives histiocytosis in SLC29A3 disorders.

bioRxiv · Dec 16, 2019 · PreprintImmunology