Cell BiologybioRxivPreprint
Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with loss of proteostasis
J. Paxman, Z. Zhou, R. O'Laughlin…·N. Hao
The paper shows that reduced rDNA stability in yeast leads to rRNA-binding protein aggregation, linking chromatin instability to proteostasis loss during aging.
DOI 10.1101/2021.12.06.471495