R. Pena-Miller

The paper investigates how antimicrobial resistance levels and conjugation permissiveness influence plasmid distribution in clinical enterobacteria, showing that specific bacterial clones stabilize plasmid spread.

This study shows that multi-copy plasmids in E. coli generate antibiotic heteroresistance through copy number variability, enabling transient resistance and population regeneration.

The paper models plasmid copy number optimization in bacteria under fluctuating selection, showing it depends on environmental change rates and balances stability with metabolic cost.

The study determines the distribution of fitness effects for plasmid pOXA-48 in gut bacteria, showing quasi-neutral effects and beneficial effects in some isolates, and links plasmid persistence to bacterial diversity and phylogeny.

This study shows genetic dominance influences the evolution and spread of mobile genetic elements in bacteria by favoring dominant mutations and silencing recessive alleles in horizontally transferred genes.

The paper shows that tradeoffs between host-parasite traits can become tradeups, supporting biodiversity through high-dimensional trait interactions.