Author

R. Piskol

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. Scherl· 1 shared B. M. Kamath· 1 shared C. L. Gilchrist· 1 shared C. W. Siebel· 1 shared D. Sangaraju· 1 shared E. C. Dueber· 1 shared E. Helgason· 1 shared F. K. Choudhury· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

A. Scherl

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Author profile →

2 papers

Recent·Most cited

Constitutive protein degradation induces acute cell death via proteolysis products

S.-H. Chen, S. Prakash, E. Helgason, C. L. Gilchrist, L. R. Kenner, R. Srinivasan, T. Sterne-Weiler, M. Hafner, R. Piskol, E. C. Dueber, H. Hamidi, N. Endres, X. Ye, W. J. Fairbrother, I. E. Wertz

This study shows proteasome-generated peptides from degraded proteins induce cell death by neutralizing IAPs, explaining the efficacy of proteolysis-modulating drugs like thalidomide analogs and bortezomib.

bioRxiv · Feb 6, 2023 · PreprintCell Biology

Discovery of thyrocyte heterogeneity reveals an essential role of Notch signaling in thyroid function and mammalian homeostasis

L. Mosteiro, T. T. T. Nguyen, S. Hankeova, M. Reichelt, S. M. Vandriel, Z. Lai, F. K. Choudhury, D. Sangaraju, B. M. Kamath, A. Scherl, R. Piskol, C. W. Siebel

The paper identifies thyrocyte subtypes in adult mouse thyroid and shows Notch signaling regulates mitochondrial function and thyroid hormone levels, linking it to hypothyroidism in Alagille Syndrome.

bioRxiv · Sep 2, 2022 · PreprintCell Biology