Z. Lai

Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma

This study shows that inhibiting SUMOylation with TAK-981 stabilizes cBAF complexes and disrupts the SS18::SSX-driven transcriptome in synovial sarcoma, leading to tumor inhibition.

Differential response of Senna occidentalis L. to arsenic and cadmium contaminated soil

This study evaluates how Senna occidentalis responds to arsenic and cadmium contamination, finding arsenic more toxic and leading to greater biomass reduction and stress indicators.

Requirement of GrgA for Chlamydia infectious progeny production, optimal growth, and efficient plasmid maintenance

This paper shows that GrgA is essential for Chlamydia growth, plasmid maintenance, and differentiation, and identifies its role in regulating sigma factors and gene expression.

A new tractable method for generating Human Alveolar Macrophage Like cells in vitro to study lung inflammatory processes and diseases

This paper develops a method to generate human alveolar macrophage-like cells in vitro using lung lipids and cytokines, enabling study of lung inflammatory diseases and infections.

Plant selection and ecological microhabitat drive domestications of shrub-associated microbiomes in a revegetated shrub ecosystem

This study examines how plant selection and ecological microhabitats influence the microbiomes of revegetated shrubs, finding that microhabitats, not plant species, primarily drive microbial community composition.

Discovery of thyrocyte heterogeneity reveals an essential role of Notch signaling in thyroid function and mammalian homeostasis

The paper identifies thyrocyte subtypes in adult mouse thyroid and shows Notch signaling regulates mitochondrial function and thyroid hormone levels, linking it to hypothyroidism in Alagille Syndrome.

RNA Methylome Reveals the m6A-Mediated Regulation of Flavor Metabolites in Tea Leaves under Solar-Withering

The paper investigates m6A-mediated regulation of flavor metabolites in tea leaves during solar-withering, identifying key m6A erasers and their impact on terpenoid and flavonoid biosynthesis.

Novel aspects of iron homeostasis in pathogenic bloodstream form Trypanosoma brucei

This study identifies novel iron regulatory mechanisms in Trypanosoma brucei, revealing an RNA binding protein RBP5 that regulates iron homeostasis through a post-transcriptional feedback mechanism.

Bactericidal efficiency and mechanism of specifically targeted antimicrobial peptides optimized based on structural and functional relationships

This study optimizes antimicrobial peptides to enhance their activity and specificity against E. coli by modifying structure and introducing a phage-displayed targeting moiety.

The Kobresia pygmaea ecosystem of the Tibetan highlands – origin, functioning and degradation of the world’s largest pastoral alpine ecosystem

This paper reviews the origin, functioning, and degradation of the Kobresia pygmaea ecosystem in the Tibetan highlands, identifying key factors affecting its resilience and carbon dynamics.