Author

N. Endres

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

M. Hafner· 2 shared A. Dey· 1 shared A. Olivero· 1 shared C. L. Gilchrist· 1 shared D. Kirkpatrick· 1 shared D. Sampath· 1 shared E. C. Dueber· 1 shared E. Hanan· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

M. Hafner

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Constitutive protein degradation induces acute cell death via proteolysis products

S.-H. Chen, S. Prakash, E. Helgason, C. L. Gilchrist, L. R. Kenner, R. Srinivasan, T. Sterne-Weiler, M. Hafner, R. Piskol, E. C. Dueber, H. Hamidi, N. Endres, X. Ye, W. J. Fairbrother, I. E. Wertz

This study shows proteasome-generated peptides from degraded proteins induce cell death by neutralizing IAPs, explaining the efficacy of proteolysis-modulating drugs like thalidomide analogs and bortezomib.

bioRxiv · Feb 6, 2023 · PreprintCell Biology

RTK-dependent inducible degradation of mutant PI3K alpha drives GDC-0077 (Inavolisib) efficacy

K. Song, K. Edgar, E. Hanan, M. Hafner, J. Oeh, M. Merchant, D. Sampath, M. Nannini, R. Hong, L. Phu, W. Forrest, E. Stawiski, S. schmidt, N. Endres, J. Guan, , L. Friedman

The paper shows that GDC-0077 and taselisib degrade mutant PI3K alpha via HER2-dependent mechanisms, enhancing efficacy in PIK3CA-mutant breast cancer.

bioRxiv · May 12, 2021Cancer Biology