Metallo-protease Peptidase M84 from Bacillus altitudinis induces ROS dependent apoptosis in ovarian cancer cells by targeting PAR-1
N. Nag, T. Ray, R. Tapader, A. Gope, R. Das, E. Mahapatra, S. Saha, A. Pal, P. Prasad, S. Chatterjee, S. S. Roy, A. Pal
This paper identifies Peptidase M84 from Bacillus altitudinis as an apoptosis inducer in ovarian cancer cells via PAR-1 mediated oxidative stress, showing anti-tumor effects in vitro and in vivo.
bioRxiv · Sep 6, 2023 · PreprintCancer Biology