P. Prasad

TGFb-ANGPT2-Tie2 axis in cancer-associated fibroblasts reprograms oral cancer cells to embryonic-like cell state with predictive significance of poor prognosis

The paper identifies the TGFβ-ANGPT2-Tie2 axis in cancer-associated fibroblasts that reprograms oral cancer cells to an embryonic-like state, linked to poor prognosis.

Age-related MICOS Complex Dysregulation Impairs Mitochondrial 3D Architecture and Metabolic Homeostasis in the Liver

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

Impedance-based assay for pan-cancer early and rapid detection of cell-free DNA

This paper introduces an impedance-based biosensor for rapid, label-free detection of cancer-associated cfDNA with high sensitivity and specificity across multiple cancer types.

Metabolite accumulation from oral NMN supplementation drives aging-specific kidney inflammation

This study shows that NMN supplementation in aged mice increases kidney inflammation and uremic toxins, suggesting age-specific risks of NAD+ boosting supplements.

Experimental type 1 diabetes metabolically rejuvenates CD8+ T cells for improved control of tumor growth through an IGF1-IGF1R axis

This study shows that experimental type 1 diabetes enhances CD8+ T cell function via the IGF1-IGF1R axis, leading to better tumor control.

Improved bladder cancer antitumor efficacy with a recombinant BCG that releases a STING agonist

This study evaluates a recombinant BCG strain that releases a STING agonist, showing improved antitumor efficacy in bladder cancer models compared to wild-type BCG.

Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts

This study identifies structural and metabolic changes in human heart failure using SBF-SEM and metabolomic analyses.

Metallo-protease Peptidase M84 from Bacillus altitudinis induces ROS dependent apoptosis in ovarian cancer cells by targeting PAR-1

This paper identifies Peptidase M84 from Bacillus altitudinis as an apoptosis inducer in ovarian cancer cells via PAR-1 mediated oxidative stress, showing anti-tumor effects in vitro and in vivo.

Huntingtin Interacting Protein-1 expression is regulated via HIF2 axis in Lung Adenocarcinoma

The paper investigates HIP1 expression regulation via the HIF2 axis in lung adenocarcinoma, showing its role in tumor suppression and metabolic changes.

Transgenic Mouse Models Establish a Protective Role of Type 1 IFN Response in SARS-CoV-2 infection-related Immunopathology

This study uses transgenic mouse models to show that a heightened type 1 IFN response protects against SARS-CoV-2-induced immunopathology, with Irgm1 as a potential therapeutic target.

3D Reconstruction of Murine Mitochondria Exhibits Changes in Structure Across Aging Linked to the MICOS Complex

This study examines age-related changes in mitochondrial 3D structure in mouse muscle and heart tissues, linking these changes to the MICOS complex and metabolic alterations.

Adjunctive inhibition of the integrated stress response pathway accelerates bacterial clearance in a mouse model of tuberculosis

This study shows that inhibiting the Integrated Stress Response (ISR) pathway alongside standard TB antibiotics reduces bacterial loads and accelerates sterilization in a mouse model of tuberculosis.

Isolation and Characterization of SARS-CoV-2 strains circulating in Eastern India.

The paper isolates and characterizes five SARS-CoV-2 strains from India, showing variations in cytotoxicity and cell line permissiveness, and finds both Covaxin and Covishield vaccines neutralize all isolates effectively.

Horizontal transfer of a conserved npc-2 like effector gene in rust fungi that suppresses cell death in plants

The paper identifies a horizontally transferred NPC2-like effector gene from rust fungi that suppresses plant cell death by lipid binding, showing functional conservation with animal NPC2 proteins.

Comparative secretomics identifies conserved WAxR motif-containing effectors in rust fungi that suppress cell death in plants

This study identifies a novel WAxR motif in rust fungal effectors that suppress plant cell death, using comparative secretome analysis and functional validation.

Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host-factors having implication in the disease pathogenesis and severity

This study uses quantitative proteomics to analyze SARS-CoV-2-infected hamster lung tissues, identifying differentially expressed proteins and pathways linked to disease pathogenesis and severity.

Unravelling cotton RNAseq repositories to the fiber development specific modules and their alliance with the fiber-related traits

The paper analyzes RNAseq data from cotton to identify gene modules associated with fiber development stages and links them to fiber-related traits.

Molecular basis of the logical evolution of the novel coronavirus SARS-CoV-2: A comparative analysis

This study compares the SARS-CoV-2 spike protein structure with other coronaviruses to identify amino acid changes responsible for increased infectivity and conformational flexibility.

Autoimmunity Risk Gene IRGM is a Master Negative Regulator of Interferon Response by Controlling the Activation of cGAS STING and RIG-I-MAVS Signaling Pathways

This study identifies IRGM as a negative regulator of interferon response by controlling cGAS-STING and RIG-I-MAVS pathways, linking its deficiency to autoimmunity and antiviral resistance.