Cancer BiologybioRxivPreprint
BRCA1 Hypermethylation In Sporadic Breast Cancers: Discovering A Novel Pathway To Tumorigenesis Via Coordinate NBR2 Deregulation And TNBC Transformation
D. Patra, G. R. Varghese, V. S. Jaikumar…·P. Srinivas
This study identifies a novel pathway in sporadic breast cancers where BRCA1 hypermethylation leads to NBR2 deregulation, TNBC transformation, and aggressive tumor behavior through altered transcript ratios and hormone receptor dynamics.
DOI 10.1101/2022.04.30.490082