Author

P. Srinivas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:structural biology· 3 Organism:bacteria (other)· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. M. Dunham· 3 shared D. Dey· 2 shared G. L. Conn· 2 shared L. R. Comstock· 2 shared N. Zelinskaya· 2 shared A. E. Jerse· 1 shared A. Mehrani· 1 shared A. Rajan· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersBiochemistry

C. M. Dunham

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Umbrella toxin particles produced by Streptomyces block mycelial growth of competing species

Q. Zhao, S. Bertolli, Y.-J. Park, Y. Tan, K. J. Cutler, P. Srinivas, K. L. Asfahl, C. Fonseca Garcia, L. A. Gallagher, Y. Li, Y. Wang, D. Coleman-Derr, F. DiMaio, D. Zhang, S. B. Peterson, , J. D. Mougous

This study identifies umbrella toxin particles produced by Streptomyces that inhibit the growth of competing bacterial species, distinct from small molecule antibiotics.

bioRxiv · Dec 9, 2023 · PreprintMicrobiology

30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC

P. Srinivas, M. Nosrati, N. Zelinskaya, D. Dey, L. R. Comstock, C. M. Dunham, G. L. Conn

This paper determines the structure of RmtC bound to the 30S ribosomal subunit and identifies key residues involved in G1405 modification, providing insights for inhibitor development.

Proceedings of the National Academy of Sciences · Jun 12, 2023Peer-reviewedBiochemistry

BRCA1 Hypermethylation In Sporadic Breast Cancers: Discovering A Novel Pathway To Tumorigenesis Via Coordinate NBR2 Deregulation And TNBC Transformation

D. Patra, G. R. Varghese, V. S. Jaikumar, A. Rajan, N. Krishnan, K. Kuppuswamy, R. Thankappan, P. Srinivas

This study identifies a novel pathway in sporadic breast cancers where BRCA1 hypermethylation leads to NBR2 deregulation, TNBC transformation, and aggressive tumor behavior through altered transcript ratios and hormone receptor dynamics.

bioRxiv · Apr 30, 2022 · PreprintCancer Biology

50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA

Z. T. Laughlin, S. Nandi, D. Dey, N. Zelinskaya, M. A. Witek, P. Srinivas, H. A. Nguyen, E. G. Kuiper, L. R. Comstock, C. M. Dunham, G. L. Conn

This paper reports the structure of the Mycobacterium tuberculosis TlyA enzyme bound to the 50S ribosomal subunit, revealing mechanisms of rRNA substrate recognition and modification that contribute to antibiotic resistance.

bioRxiv · Nov 11, 2021Biochemistry

Ribosome rescue inhibitors clear Neisseria gonorrhoeae in vivo using a new mechanism

Z. D. Aron, A. Mehrani, E. D. Hoffer, K. L. Connolly, M. C. Torhan, J. N. Alumasa, P. Srinivas, M. Cabrera, D. Hosangadi, J. S. Barbor, S. C. Cardinale, S. M. Kwasny, L. R. Morin, M. M. Butler, T. J. Opperman, , K. C. Keiler

The paper describes the development of ribosome rescue inhibitors that clear drug-resistant Neisseria gonorrhoeae in vivo through a novel mechanism involving ribosomal conformational changes.

bioRxiv · Jun 4, 2020 · PreprintMicrobiology