Author

R. Tooze

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

G. Doody· 2 shared M. A. Care· 2 shared A. A. A. Mohamed· 1 shared A. Clear· 1 shared A. Psarras· 1 shared A. Q. Xu· 1 shared A. Zougman· 1 shared B. Zhang· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

G. Doody

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Author profile →

4 papers

Recent·Most cited

Co-activation of NF-κB and MYC renders cancer cells addicted to IL6 for survival and phenotypic stability

R. Barbosa, A. Q. Xu, D. D'Andrea, F. Copley, H. Patel, P. Chakravarty, A. Clear, M. Calaminici, M. Janz, B. Zhang, M. Schmidt-Supprian, J. Wang, J. Gribben, R. Tooze, J. Fitzgibbon, , D. P. Calado

This paper shows that co-activation of NF-κB and MYC in cancer cells makes them dependent on IL6 for survival and leads to a poorly-differentiated state similar to human plasmablastic lymphoma and t(8;14)[MYC-IGH] multiple myeloma.

bioRxiv · Apr 12, 2020 · PreprintCancer Biology

A dichotomy in association of core transcription factors and gene regulation during the activated B-cell to plasmablast transition.

M. Cocco, M. A. Care, M. Al-Maskari, G. M. Doody, R. Tooze

This study identifies a dichotomy in the association of core transcription factors with gene regulation during the activated B-cell to plasmablast transition, showing IRF4 and XBP1 drive ASC gene expression while BLIMP1 represses ABC genes.

bioRxiv · Dec 23, 2019 · PreprintImmunology

B cell tetherin: a flow-cytometric cell-specific assay for response to Type-I interferon predicts clinical features and flares in SLE

Y. M. El-Sherbiny, M. Y. Md Yusof, A. Psarras, E. M. A. Hensor, K. Z. Kabba, K. Dutton, A. A. A. Mohamed, D. Elewaut, D. McGonagle, R. Tooze, G. Doody, M. Wittmann, P. Emery, E. Vital

The paper develops a flow-cytometric assay measuring B cell tetherin expression to predict SLE diagnosis, disease activity, and flares, showing stronger associations than other markers.

bioRxiv · Feb 19, 2019Immunology

Growth-factor like gene regulation is separable from survival and maturation in antibody secreting cells

S. S. Stephenson, M. A. Care, I. Fan, A. Zougman, D. Westhead, G. Doody, R. Tooze

The paper shows that growth factor-like gene regulation in human antibody secreting cells is transient and distinct from survival and maturation processes.

bioRxiv · Oct 11, 2018Immunology