P. Chakravarty

Blimp-1 and c-Maf regulate common and unique gene networks to protect against distinct pathways of pathobiont-induced colitis

This study shows Blimp-1 and c-Maf regulate gene networks in T cells to prevent colitis, with distinct roles in controlling inflammatory pathways in mouse models.

Epi-microRNA mediated metabolic reprogramming ensures affinity maturation

This study identifies miR-155's role in metabolic reprogramming of GC-B cells to support affinity maturation under hypoxic conditions.

Regulation of BCR-mediated Ca2+ mobilization by MIZ1-TIMBIM4 safeguards IgG1+ GC B cell positive selection

This study identifies MIZ1-TMBIM4 as a mechanism safeguarding IgG1+ GC B cell positive selection by regulating Ca2+ mobilization and preventing mitochondrial dysfunction.

Cancer cell - fibroblast crosstalk via HB-EGF/EGFR/MEK signalling promotes macrophage recruitment in squamous cell carcinoma

The paper identifies a gene expression signature of cancer-fibroblast crosstalk in squamous cell carcinoma and shows its prognostic relevance and role in macrophage recruitment.

PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma

This study identifies PHGDH as essential for germinal center formation and shows its inhibition reduces lymphoma progression and improves survival.

Synergistic interactions between Stachybotrys chartarum and other indoor fungal species in moisture-damaged houses

This study examines the interactions between Stachybotrys chartarum and other indoor fungi in moisture-damaged houses, finding antagonistic effects against some species and no effect on others.

Early functional mismatch between breast cancer cells and their tumour microenvironment suppresses long term growth

The paper shows that aggressive breast cancer cells, when forced to grow in an atypical microenvironment, experience long-term growth suppression due to anti-tumoural macrophages.

N-myristoyltransferase inhibition is synthetic lethal in MYC-deregulated cancers

N-myristoyltransferase inhibition causes mitochondrial dysfunction and cell death in MYC-deregulated cancers through post-transcriptional failure in complex I synthesis.

EphB6 regulates TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells

This study identifies EphB6 as a regulator of the TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells in a foreign environment.

Critical role of WNK1 in MYC-dependent early thymocyte development

This study identifies WNK1 as essential for thymocyte development by regulating ion homeostasis and MYC expression during the transition from double negative to double positive thymocytes.

SOX2 is required independently in both stem and differentiated cells for pituitary tumorigenesis in p27 null mice.

This study shows SOX2 is required in both stem and differentiated cells for pituitary tumorigenesis in p27 null mice, highlighting distinct roles of SOX2 in different cell types.

Co-activation of NF-κB and MYC renders cancer cells addicted to IL6 for survival and phenotypic stability

This paper shows that co-activation of NF-κB and MYC in cancer cells makes them dependent on IL6 for survival and leads to a poorly-differentiated state similar to human plasmablastic lymphoma and t(8;14)[MYC-IGH] multiple myeloma.