Regulatory sites in the Mon1-Ccz1 complex control Rab5 to Rab7 transition and endosome maturation
A.-C. Borchers, M. Janz, J.-H. Schaefer, A. Moeller, D. Kuemmel, A. Paululat, C. Ungermann, L. Langemeyer
bioRxiv · Mar 1, 2023Cell Biology
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M. Janz
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
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2020-2023 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 15 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship5 papers
Recent·Most cited
Preclinical models of human multiple myeloma subgroups
W. Winkler, C. Farre Diaz, E. Blanc, H. Napieczynska, P. Langner, M. Werner, B. Walter, B. Wollert-Wulf, T. Yasuda, A. Heuser, D. Beule, S. Mathas, I. Anagnostopoulos, A. Rosenwald, K. Rajewsky, M. Janz
This study generates preclinical models of human multiple myeloma subgroups by inducing specific genetic alterations in mice, showing their resemblance to human disease.
bioRxiv · Aug 28, 2021 · PreprintCancer Biology
N-myristoyltransferase inhibition is synthetic lethal in MYC-deregulated cancers
G. A. Lueg, M. Faronato, A. Gorelik, A. Goya Grocin, E. Caamano-Gutierrez, F. Falciani, R. Solari, R. Carr, A. S. Bell, E. Bartlett, J. A. Hutton, M. Llorian-Sopena, P. Chakravarty, B. Brzezicha, M. Janz, , E. W. Tate
N-myristoyltransferase inhibition causes mitochondrial dysfunction and cell death in MYC-deregulated cancers through post-transcriptional failure in complex I synthesis.
bioRxiv · Mar 20, 2021 · PreprintCancer Biology
Co-activation of NF-κB and MYC renders cancer cells addicted to IL6 for survival and phenotypic stability
R. Barbosa, A. Q. Xu, D. D'Andrea, F. Copley, H. Patel, P. Chakravarty, A. Clear, M. Calaminici, M. Janz, B. Zhang, M. Schmidt-Supprian, J. Wang, J. Gribben, R. Tooze, J. Fitzgibbon, , D. P. Calado
This paper shows that co-activation of NF-κB and MYC in cancer cells makes them dependent on IL6 for survival and leads to a poorly-differentiated state similar to human plasmablastic lymphoma and t(8;14)[MYC-IGH] multiple myeloma.
bioRxiv · Apr 12, 2020 · PreprintCancer Biology
Pdap1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification
V. Delgado-Benito, M. Berruezo-Llacuna, R. Altwasser, W. Winkler, S. Balasubramanian, D. Sundaravinayagam, R. Graf, A. Rahjouei, M. Driesner, L. Keller, M. Janz, A. Akalin, M. Di Virgilio
This study identifies Pdap1 as a regulator of mature B cell survival and antibody gene diversification by modulating the integrated stress response and AID expression.
bioRxiv · Jan 30, 2020Immunology