Author

R. Upstill-Goddard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:differential expression· 1

Frequent Co-Authors

U.-M. Bailey· 2 shared A. Ashworth· 1 shared A. Biankin· 1 shared A. D. Campbell· 1 shared A. DeFazio· 1 shared A. Gulati· 1 shared A. Johns· 1 shared A. K. Najumudeen· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

U.-M. Bailey

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Author profile →

3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 29, 2023

Kras loss of heterozygosity promotes MAPK dependent pancreatic ductal adenocarcinoma and induces therapeutic sensitivity

S. K. Fey, A. K. Najumudeen, C. A. Ford…·O. J. Sansom

This study shows that loss of wild-type Kras enhances oncogenic Kras signaling and promotes pancreatic ductal adenocarcinoma, while also increasing sensitivity to MEK1/2 inhibitors.

DOI 10.1101/2023.08.29.552598

mouseexperimental assay

𝕏 PostBluesky

Cancer BiologybioRxivPreprintNov 24, 2020

Ovarian carcinosarcoma genomics and pre-clinical models highlight the N-MYC pathway as a key driver and susceptibility to EMT-targeting therapy

G. Y. Ho, E. Kyran, J. Bedo…·H. Barker

This study identifies N-MYC pathway activation and susceptibility to EMT-targeting therapy in ovarian carcinosarcoma using genomic and pre-clinical models.

DOI 10.1101/2020.11.24.396796

humanDNA methylation

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Cancer BiologybioRxivJul 24, 2019

Targeting DNA damage response and Replication Stress in Pancreatic Cancer

S. Dreyer, R. Upstill-Goddard, V. Paulus-Hock…·Lord

The paper identifies novel therapeutic strategies for pancreatic cancer by analyzing DNA damage response and replication stress in patient-derived cell lines.

DOI 10.1053/j.gastro.2020.09.043

humanbulk RNA-seq

𝕏 PostBluesky