ImmunologybioRxiv
Autoreactive T cells preferentially drive differentiation of non-responsive memory B cells at the expense of germinal center maintenance.
R. W. Jain, K. A. Parham, Y. Tesfagiorgis…·S. M. Kerfoot
The paper compares B cell fate outcomes in responses to autoantigen MOG and foreign antigen NPOVA, showing that autoreactive T cells drive memory B cell differentiation at the expense of germinal center maintenance.
DOI 10.1016/j.celrep.2018.11.070