Author

Rachel G. Knox

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Bart Vanhaesebroeck· 1 shared Franziska VöllmyiD· 1 shared Gemma V. BrierleyiD· 1 shared Helen C. SuiD· 1 shared James LongdeniD· 1 shared Kenneth G. Macleod· 1 shared Larissa S. Moniz· 1 shared Neil O. Carragher· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Bart Vanhaesebroeck

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2 papers

Recent·Most cited

BiochemistrybioRxivNov 2, 2023

Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant

Patsy R Tomlinson, Rachel G. Knox, Olga Perišić…·Robert K. Semple

The paper investigates an activating PIK3R1 variant linked to immunodeficiency and finds it acts as a dominant negative, reducing p110 signaling and explaining overlapping phenotypes.

3 citations

humanproteomics

𝕏 PostBluesky

Cancer BiologyDisease Models & MechanismsPeer-reviewedMar 11, 2021

NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CAH1047R homozygosity in pluripotent stem cells

Ralitsa R. Madsen, James Longden, Rachel G. Knox…·Robert K. Semple

This study shows that PIK3CAH1047R homozygosity in hPSCs leads to self-sustained stemness via enhanced NODAL/TGFβ signalling, which can be reversed by TGFβ inhibition.

DOI 10.1242/dmm.048298

humanbulk RNA-seq

𝕏 PostBluesky