NeuroscienceNeurobiology of DiseasePeer-reviewed
Cell-intrinsic effects of TorsinA(ΔE) disrupt dopamine release in a mouse model of DYT1-TOR1A dystonia
Anthony M. Downs, Xueliang Fan, Radhika F. Kadakia…·Ellen J. Hess
This study shows that the Tor1a(ΔE) mutation in dopamine neurons reduces dopamine release, while having no effect in cholinergic neurons, indicating a cell-intrinsic role in dystonia.
18 citations