Cancer BiologybioRxivPreprint
Targeting the dysfunctional mitochondrial respiration in drug resistant B-cell acute lymphoblastic leukemia
Rajesh R. Nair, Debbie Piktel, Patrick Thomas…·Laura F. Gibson
This study identifies mitochondrial respiration dysfunction in drug-resistant ALL cells and shows that pyrvinium pamoate (PP) effectively targets this pathway, with enhanced bioavailability and specificity for leukemic cells.
DOI 10.1101/595959