NeuroscienceNeurobiology of DiseasePeer-reviewed
The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology.
Jennifer Stables, Reiss Pal, Barry Matthew Bradford…·David Arthur Hume
This study examines the impact of a heterozygous Csf1r mutation on brain development and neuropathology in mice, showing reduced microglial abundance and altered gene expression in disease models.
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