Author

Richard Dean

Department of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, BC V5G 4W8, Canada

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:electrophysiology· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 1

Frequent Co-Authors

Fiona Scott· 2 shared Janette Mezeyova· 2 shared JP JohnsoniD· 2 shared Matthew Waldbrook· 2 shared Noah Gregory Shuart· 2 shared Samuel J. GoodchildiD· 2 shared Thilo FockeniD· 2 shared Aaron D. Williams· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersPharmacology & Toxicology

Fiona Scott

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivAug 3, 2023

Molecular pharmacology of selective NaV1.6 and dual NaV1.6 and NaV1.2 channel inhibitors that suppress excitatory neuronal activity ex vivo

Samuel J. Goodchild, Noah Gregory Shuart, Aaron D. Williams…·JP Johnson

This paper introduces selective NaV1.6 and dual NaV1.6/NaV1.2 inhibitors that suppress excitatory neuronal activity ex vivo, showing selectivity over NaV1.1 and efficacy in seizure models.

DOI 10.1021/acschemneuro.3c00757

electrophysiologyexperimental assay

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivPreprintAug 3, 2023

NaV1.6 inhibition drives the efficacy of voltage-gated sodium channel inhibitors to prevent electrically induced seizures in both wild type and Scn8aN1768D/+ gain-of-function mice

JP Johnson, Thilo Focken, Parisa Karimi Tari…·James R Empfield

The paper shows that inhibiting NaV1.6 reduces seizures in both wild-type and Scn8aN1768D/+ mice, suggesting NaV1.6 is a key target for anti-seizure drugs.

DOI 10.1101/2023.08.03.551823

mouseelectrophysiology

𝕏 PostBluesky