Author

Samuel J. Goodchild

Xenon Pharmaceuticals (Canada)ORCID 0000-0001-9805-1743Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:electrophysiology· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:electronic health records· 1

Frequent Co-Authors

Janette Mezeyova· 3 shared Matthew Waldbrook· 3 shared Charles J. Cohen· 2 shared James P. JohnsoniD· 2 shared Maegan Soriano· 2 shared Noah Gregory Shuart· 2 shared R. Ryley ParrishiD· 2 shared Richard A. DeaniD· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPharmacology & Toxicology

Janette Mezeyova

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Pharmacology & ToxicologyBritish Journal of PharmacologyPeer-reviewedJun 24, 2024

NaV1.6 inhibition drives the efficacy of voltage-gated sodium channel inhibitors to prevent electrically induced seizures in both wild type and Scn8aN1768D/+ gain-of-function mice

James P. Johnson, Thilo Focken, Parisa Karimi Tari…·James R. Empfield

The paper shows that inhibiting NaV1.6 reduces seizures in both wild-type and Scn8aN1768D/+ mice, suggesting NaV1.6 is a key target for anti-seizure drugs.

9 citations

mouseelectrophysiology

𝕏 PostBluesky

Pharmacology & ToxicologyACS Chemical NeurosciencePeer-reviewedFeb 15, 2024

Molecular pharmacology of selective NaV1.6 and dual NaV1.6 and NaV1.2 channel inhibitors that suppress excitatory neuronal activity ex vivo

Samuel J. Goodchild, Noah Gregory Shuart, Aaron D. Williams…·James P. Johnson

This paper introduces selective NaV1.6 and dual NaV1.6/NaV1.2 inhibitors that suppress excitatory neuronal activity ex vivo, showing selectivity over NaV1.1 and efficacy in seizure models.

36 citationstop 4%

electrophysiologyexperimental assay

𝕏 PostBluesky

NeuroscienceFrontiers in Cellular NeurosciencePeer-reviewedSep 29, 2022

Pharmacological determination of the fractional block of Nav channels required to impair neuronal excitability and ex vivo seizures

Samrat Thouta, Matthew Waldbrook, Sophia Lin…·R. Ryley Parrish

The paper determines the fractional block of Nav channels needed to impair neuronal excitability and reduce seizure-like activity using TTX in pyramidal neurons.

16 citations

mouseelectronic health records

𝕏 PostBluesky