Richard M Murray

The paper designs a library of RNA thermometers with varying temperature responses, validated experimentally and computationally.

This paper demonstrates that synthetic gene networks can be designed, characterized, and engineered in a cell-free system and successfully transferred to living cells, showing their applicability in both in vitro and in vivo contexts.

This paper analyzes how time-varying temperature affects delays in genetic networks and shows that temperature entrainment can occur even with temperature compensation mechanisms.

This paper demonstrates the use of cell-free TX-TL systems to rapidly characterize genetic networks, including an RNA transcriptional cascade and a protein-regulated incoherent feed-forward loop.

This study designs and screens qacR variants to create a vanillin sensor using computational methods and in vitro testing, identifying two mutants that respond to vanillin in both in vitro and in vivo settings.

This paper uses real algebraic geometry to analyze bistable biological circuits, showing how topological properties affect parameter space and demonstrating the utility of Sturms theorem over traditional methods.

The paper shows that yeast populations activate the galactose pathway before glucose is fully consumed, enabling faster metabolic transitions and a fitness advantage.

This paper demonstrates the use of an RNA aptamer against T7 RNA polymerase to create synthetic logic circuits and transcriptional cascades in E. coli.

This paper introduces a negative autoregulation system for synthetic genelets that matches production and demand, showing improved robustness and scalability compared to cross-activation.

The paper develops a scalable algorithm for designing combination therapies that stabilize disease evolutionary dynamics using optimization with regularization.

This study uses cell-free TX-TL systems to rapidly prototype and characterize RNA genetic circuits, showing response times of ~5 minutes per cascade step and demonstrating temporal gene expression staging.

This paper designs and implements a synthetic biomolecular concentration tracker in E. coli that tracks input protein concentration in real time using a feedback loop.