Pharmacology & ToxicologybioRxivPreprint
Effect of prescribing and deprescribing oxycodone on pain and function in a mouse model of osteoarthritis: impact of polypharmacy and sex on response
John Mach, Carina L. Blaker, Bryony L. Winters…·Sarah Nicole Hilmer
This study evaluates the effects of oxycodone prescribing and deprescribing in a mouse model of osteoarthritis, showing that polypharmacy worsens outcomes and sex differences exist in treatment response.
DOI 10.1101/2025.10.22.684045