Author

Romain Sansonetti

Institut Universitaire en Santé Mentale de Québec

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Neuroscience· 1

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Approach:experimental assay· 1 Organism:mouse· 1 Assay:proteomics· 1

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Iason KeramidisiD· 1 shared Johanna Alonso· 1 shared Katerina PapanikolopoulouiD· 1 shared Martina K. SamiotakiiD· 1 shared Patrick DesrosiersiD· 1 shared Yves De KoninckiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperNeuroscience

Iason KeramidisORCID

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1 paper

Recent·Most cited

NeuroscienceiSciencePeer-reviewedAug 28, 2025

Chronic optogenetic activation of hippocampal pyramidal neurons replicates the proteome footprint of Alzheimer's disease-like pathology

Iason Keramidis, Martina K. Samiotaki, Romain Sansonetti…·Yves De Koninck

The paper shows that sustained neuronal hyperactivity in wild-type and AD-like mice leads to proteomic changes similar to AD pathology, including memory loss and increased Aβ42 secretion.

2 citations

mouseproteomics

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