Pharmacology & ToxicologybioRxivPreprint
Exploring polycyclic scaffolds as adamantane replacements in M2 channel inhibitors of Influenza A virus
Andreea L. Turcu, Rosana Leiva, Chunlong Ma…·Santiago Vázquez
This study synthesizes and evaluates polycyclic amines as alternatives to adamantane in M2 channel inhibitors, identifying compounds effective against wild-type and mutant M2 channels and showing antiviral activity against human coronavirus 229E.